curcumol: from plant roots to cancer roots

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Curcumol: From Plant Roots to Cancer Roots

Jun 04, 2019  2. Curcumol and its natural sources. Curcumol, a bioactive sesquiterpenoid, has been isolated from numerous plants of family Zingiberaceae. These plants are mostly found in Southeast Asia, China, Indonesia, India, Peru, and West Indies 19. Curcuma, the most important genus of the family Zingiberaceae, encompasses approximately 100 species. Curcumol has been isolated from C. longa

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Curcumol: From Plant Roots to Cancer Roots

Curcumol: From Plant Roots to Cancer Roots Int J Biol Sci. 2019 Jun 4;15(8):1600-1609. doi: 10.7150/ijbs.34716. eCollection 2019. Authors Wei Wei 1 , Azhar Rasul 2 3 , Ayesha Sadiqa 3 , Iqra Sarfraz 3 , Ghulam Hussain 4 , Bushra Nageen 3 , Xintong Liu 1 ,

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Curcumol: From Plant Roots to Cancer Roots. - Abstract ...

Jun 04, 2019  Curcumol: From Plant Roots to Cancer Roots Wei Wei , 1 Azhar Rasul , 2, 3 Ayesha Sadiqa , 3 Iqra Sarfraz , 3 Ghulam Hussain , 4 Bushra Nageen , 3 Xintong Liu , 1 Nobumoto Watanabe , 5 Zeliha Selamoglu , 6 Muhammad Ali , 7 Xiaomeng Li , 2, and Jiang Li 1,

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Curcumol: From Plant Roots to Cancer Roots [Abstract]

Curcumol: From Plant Roots to Cancer Roots . Wei Wei 1, Azhar Rasul 2,3, Ayesha Sadiqa 3, Iqra Sarfraz 3, Ghulam Hussain 4, Bushra Nageen 3, Xintong Liu 1, Nobumoto Watanabe 5, Zeliha Selamoglu 6, Muhammad Ali 7, Xiaomeng Li 2 , Jiang Li 1 . 1. Dental Hospital, Jilin

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(PDF) Curcumol: From Plant Roots to Cancer Roots

Curcumol: From Plant Roots to Cancer Roots. Wei Wei 1, Azhar Rasul 2,3, Ayesha Sadiqa 3, Iqra Sarfraz 3, Ghulam Hussain 4, Bushra Nageen 3, Xintong Liu 1,

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Curcumol inhibits colorectal cancer proliferation by ...

Feb 24, 2019  Curcumol: From Plant Roots to Cancer Roots. Wei W, Rasul A, Sadiqa A, Sarfraz I, Hussain G, Nageen B, Liu X, Watanabe N, Selamoglu Z, Ali M, Li X, Li J. Int J Biol Sci, 15(8):1600-1609, 04 Jun 2019 Cited by: 3 articles PMID ...

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Curcumol: From Plant Roots to Cancer Roots [Abstract]

Curcumol: From Plant Roots to Cancer Roots . Wei Wei 1, Azhar Rasul 2,3, Ayesha Sadiqa 3, Iqra Sarfraz 3, Ghulam Hussain 4, Bushra Nageen 3, Xintong Liu 1, Nobumoto Watanabe 5, Zeliha Selamoglu 6, Muhammad Ali 7, Xiaomeng Li 2 , Jiang Li 1 . 1. Dental Hospital, Jilin

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Therapeutic Effects of Curcumol in Several Diseases; An ...

Curcumae Rhizoma, also known as Ezhu is a traditional Chinese medicine that has been used for many centuries against several diseases. The rhizome of the plant is composed of curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin), and essential volatile oils including curcumol, curdione, and germacrone.

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Curcumol inhibits KLF5-dependent angiogenesis by blocking ...

Jan 01, 2021  It is the common preliminary stage for various chronic liver diseases to transform into some forms of liver cancer . It is well known that the activation of hepatic stellate cells (HSCs) is a key event in the occurrence of liver fibrosis. ... Curcumol: from plant roots to cancer roots. Int. J. Biol. Sci., 15 (2019), pp. 1600-1609. CrossRef View ...

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Curcumol ((-)-Curcumol) Apoptosis Inducer MedChemExpress

Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae.Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathwayCurcumol suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt

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Curcumol induces HSC-T6 cell death through suppression of ...

Curcumol, the dried root of Rhizoma ... Curcumol: From Plant Roots to Cancer Roots. ... Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal ...

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Curcumol Overcomes TRAIL Resistance of Non‐Small Cell Lung ...

Oct 15, 2020  In conclusion, curcumol targets NQO2 and engages a ROS-driven ER stress-CHOP-DR5-dependent pathway to overcome TRAIL resistance of NSCLC (Figure 8H). 3 Discussion. Curcumol is a major sesquiterpenoid hemiketal compound isolated from the herbal medicine plant

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One-flowered Cancer Root

One flowered cancer root — also called one-flowered broomrape — is a native annual found from Vancouver Island and Southern British Columbia south to California, east to Florida and Newfoundland. This species is often found in damp woods and thickets, and open places from lowlands to moderate elevations in mountains.

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Conopholis americana - Wikipedia

Conopholis americana, the American cancer-root, squawroot (considered an offensive and outdated term), bumeh or bear corn, is a perennial, non-photosynthesizing (or "achlorophyllous") parasitic plant, from the family Orobanchaceae and more recently from the genus Conopholis but also listed as Orobanche, native but not endemic to North America and when blooming, resembles a pine cone or

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Figure 3 from Curcumol potentiates celecoxib-induced ...

Figure 3: Celecoxib and curcumol-induced apoptosis is mediated through the caspase-dependent mitochondrial pathway in NSCLC cells. (A) Caspase-8, caspase-9, caspase-3, and PARP expression levels in A549 cells under different treatment conditions. All gels run under the same experimental conditions and the representative images of three different experiments were cropped and shown.

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Poke Root: Potential Benefits, Side Effects, Uses, and ...

Oct 27, 2020  Poke root is a traditional herbal remedy said to treat cancer, infections, and inflammation, but the available research has only involved cell cultures or animals. The supposed benefits haven’t ...

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Conopholis americana (American Cancer-root, Bear Corn ...

Cancer-root is an herbaceous perennial parasitic plant in the boomrape (Orobanchaceae) family. There is no evidence to prove that it can cure cancer. The genus name Conopholis comes from Latin for 'cone' and 'scale' and refers to the appearance of the stems with

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Curcumol: de las raíces de las plantas a las raíces del ...

Curcumol: From Plant Roots to Cancer Roots Wei Wei , 1 Azhar Rasul , 2,3 Ayesha Sadiqa , 3 Iqra Sarfraz , 3 Ghulam Hussain , 4 Bushra Nageen , 3 Xintong Liu , 1 Nobumoto Watanabe , 5 Zeliha Selamoglu , 6 Muhammad Ali , 7 Xiaomeng Li , 2, and Jiang Li 1,

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Squawroot - Pennsylvania State University

Jul 21, 2014  Squawroot ( Conopholis americana) (also called “cancer root” or “bear cone”) is a low growing, brown, scaly plant that reaches heights of one foot at maturity. It is found often in dense clusters in oak and beech forests throughout eastern North America. The plants most closely resemble brown, scaly pine cones protruding up out of the ...

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Curcumol ameliorates lung inflammation and airway ...

Figure 1 Curcumol attenuated AHR, AR, and pulmonary inflammation in chronic asthmatic mice. (A) The chemical structure of curcumol.(B) Experimental layout to develop a mice model of chronic asthma.(C) Airway resistance of the mice was detected by the forced oscillation technique.(D) Airway tissues of the mice were stained by hematoxylin-eosin to detect AR in the mice.

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Curcumol: From Plant Roots to Cancer Roots. GreenMedInfo

Dec 31, 2018  Curcumol has potential to fight against cancer, oxidative stress, neurodegeneration, microbial infections, and inflammation. Curcumol has been documented as potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.

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Curcumol induces cell cycle arrest in colon cancer cells ...

Jan 10, 2018  Therefore, effective drugs with little adverse reaction need to be found for colorectal cancer therapy. Curcumol, a guaiane-type sesquiterpenoid hemiketal was extracted from the roots of the herb Rhizoma Curcumae. Owing to its low side effects, more and more studies focus on its bioactivity.

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Curcumol attenuates epithelial-mesenchymal transition of ...

for the treatment of cancer for more than 2,000 years (12). Curcumol is extracted from the roots of the medicinal plant Rhizoma curcumae as a guaiane-type sesquiterpenoid hemiketal (13). There is a previous study on tumor treatment in clinical or scientific research focusing on TCM treatment with low toxicity and drug resistance (14). Previous ...

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Curcumol inhibits ferritinophagy to restrain hepatocyte ...

Aug 03, 2021  Curcumol is an ingredient extracted from the volatile oil of a traditional Chinese herb zedoary turmeric. 20 Evidence has supported its efficacy in protection against liver fibrosis and hepatocellular carcinoma. 21-23 However, the effects of curcumol on NAFLD have not yet been reported. Our preliminary researches have shown that curcumol could ...

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Parthenolide: from plant shoots to cancer roots. Sigma ...

Parthenolide is the first small molecule found to be selective against cancer stem cells (CSC), which it achieves by targeting specific signaling pathways and killing cancer from its roots. In this review, we highlight the exciting journey of parthenolide, from plant shoots to cancer roots.

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Cancer Root (Conopholis americana)

Because Cancer Root doesn't produce chlorophyll, it is dependent on the host tree for its nourishment. Small clusters of flowering spikes often develop from the same root system. This plant spreads to new locations by reseeding itself. Cultivation: This parasitic plant is indifferent to light levels. It requires the presence of an Oak tree or ...

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medicinal herbs: CANCER ROOT - Orobanche fasciculata

The root is pectoral. The chewed root has been used as a dressing on wounds and open sores. An infusion of the leaves is used as a wash on sores. Forms of the plant that are parasitic on sweet sage roots have been used as a treatment of cancer. The dried and powdered plant is inserted in the rectum as a specific treatment for haemorrhoids.

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Scientists Find Root That Kills 98% Of Cancer Cells In ...

This root has been used medicinally since ancient times for its various health benefits. However, the most powerful benefit to come out of this common weed is something that medical researchers are super excited to have “discovered” – which is its potential to cure cancer! This potent root builds up blood and immune system- cures prostate, []

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Dandelion Root Can Help Cancer Patients 1MD Nutrition™

A further benefit reported was that the root extract also induced autophagy, which is the body's natural process of removing debris and damaged cells (such as cancer cells). In 2015, the Windsor Regional Cancer Center received approval and funding for human clinical trials to evaluate the impact of dandelion root on cancer patients.

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List of Greek and Latin roots in English

List of Greek and Latin roots in English 2 anem-wind Greek ἄνεμος anemos anemometeranim-breath Latin anima "breath" animal, animationann-, -enn-year, yearly Latin annus "year" anniversary, annual,biannual, millennium ant-, anti-against, opposed to, preventive Greek ἀντί anti "against" antagonist, antibiotic,antipodes ante-, anti-before, in front of, prior to Latin ante "before ...

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Pulling Cancer’s Roots - Vanderbilt-Ingram Cancer Center

Jul 11, 2008  Pulling Cancer’s Roots. Every gardener knows that to truly eliminate a weed, you have to pull out the root. Nip the weed off at the surface only, and in time it will grow back. Such might also be the case with cancer – treatments aimed at shrinking tumors may be leaving behind the “roots,” a core of cells with the unique capacity to ...

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Frontiers Curcumol Exerts Anticancer Effect in ...

Mar 20, 2018  Curcumol is the major component extracted from root of Rhizoma Curcumae. Recent studies have shown that curcumol exerts therapeutic effects against multiple conditions, particularly cancers. However, the therapeutic role and mechanism of curcumol against cholangiocarcinoma cells are still unclear. In our current research, we tested the effect of curcumol in cholangiocarcinoma

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Marshmallow Root Benefits, Uses, Risks, Side Effects and ...

Mar 04, 2021  Supplements, teas or tinctures that contain marshmallow root extract are made by isolating special compounds found in Althaea officinalis leaves and roots. The flowers and young leaves of the marshmallow plant are also edible and traditionally have

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Product Data Sheet - MedchemExpress

Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers[1]. In Vitro Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae. Curcumol exerts anticancer

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